Stress to an individual, can either be positive or negative depending on various things, such as conditions or environment under which individuals experience it and circumstances under which the experience occurs. In addition, people of all ages experience stress somewhat. Consequently, the objective of the study was to examine factors that precipitate stress in pastors’ wives and determine whether stress to Pastors’ wives do affect church ministry performance. Further, if stress to pastors’ wives has any effect on church performance, the study sought to suggest solutions to mitigate stressful conditions so as to improve the performance of church ministries. Accordingly, the study investigated stress symptoms that are exhibited by Pastors’ spouses; factors that cause them stress and the evidence of how stress to Pastors’ wives affects performance of Church ministries.